2-Aminothiazole → C-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-methanesulfonamide

HRID 1159469Notes

Reaction equation

HRID 1159469 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][S:12](Cl)(=[O:14])=[O:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[NH2:16][C:17]1[S:18][CH:19]=[CH:20][N:21]=1>N1C=CC=CC=1>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][S:12]([NH:16][C:17]2[S:18][CH:19]=[CH:20][N:21]=2)(=[O:14])=[O:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 21552-AminothiazoleHCID 219624184-(Methylsulfonyl)benzenemethanesulfonyl chloride

Product 1

HCID 86602239C-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-methanesulfonamide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To the solution of the title B compound, (4-methanesulfonyl-phenyl)-methanesulfonyl chloride (1.86 mmol, 0.5 g) in 5 mL of pyridine is added 2-aminothiazole (2.5 mmol, 0.25 g) and the mixture is stirred for 48 h. The reaction mixture is quenched with aqueous 1 N HCl and the product is taken up in EtOAc, dried and concentrated to afford C-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-methanesulfonamide.

Workup

  1. customThe reaction mixture is quenched with aqueous 1 N HCl
  2. customdried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-e647cf369cb744ceabbcc9d074c9dcf1
Source dataset
uspto-grants-2010_10
Patent number
US07812167B2

Reaction notes

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