Hydrochloric Acid → HCID 68442806, compound

HRID 1159476Notes

Reaction equation

HRID 1159476 reaction equation
C[O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:5]=1[O:14][CH2:15][C:16]([O:18]CC)=[O:17].[OH-].[Na+].Cl>CO>[C:16]([CH2:15][O:14][C:5]1[CH:6]=[C:7]([C:10]([F:11])([F:13])[F:12])[CH:8]=[CH:9][C:4]=1[C:3]([OH:21])=[O:2])([OH:18])=[O:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68445477HCID 68445477, compound

Product 1

HCID 68442806HCID 68442806, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-Ethoxycarbonylmethoxy-4-trifluoromethyl-benzoic acid methyl ester (34 g), 10% NaOH (132.5 g) and methanol (45 ml) were mixed in one necked round flask. Resulting mixture was mixed at room temperature for 5 hrs. Acidified to pH 2 by 1 N HCl. Evaporated in vacuo. Filtrated and washed with water to obtain the product 5a.

Workup

  1. additionwere mixed in one necked round flask
  2. customResulting mixture
  3. additionwas mixed at room temperature for 5 hrs
  4. customEvaporated in vacuo
  5. filtrationFiltrated
  6. washwashed with water

Sources & evidence

ORD record
ord-48e632bb420b471c8efa20faa784c1f5
Source dataset
uspto-grants-2010_10
Patent number
US07812177B2

Reaction notes

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