HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-2,2-dimethyl-1-propanol → 3-[1-(3-hydroxy-2,2-dimethylpropyl)piperidin-4-yl]-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-2,2-dimethyl-1-propanol | HCID 142501 | — |
| Reactant | 3-(Piperidin-4-yl)isoquinolin-1(2H)-one hydrochloride | HCID 23082113 | — |
| Product | 3-[1-(3-hydroxy-2,2-dimethylpropyl)piperidin-4-yl]-2H-isoquinolin-1-one | HCID 10313560 | 15.2% |
Reaction Steps
By the reaction in the same manner as in Example 2a, using 3-(piperidin-4-yl)-2H-isoquinolin-1-one hydrochloride (510 mg) and 3-bromo-2,2-dimethyl-1-propanol (474 mg), 3-[1-(3-hydroxy-2,2-dimethylpropyl)piperidin-4-yl]-2H-isoquinolin-1-one (92 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812178B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-85734126d6384ab9950ecfd640efef01 |
| Source note | uspto-grants-2010_10 |