1-Bromo-2-propanol → HCID 10424886, compound

HRID 1159529Notes

Reaction equation

HRID 1159529 reaction equation
Cl.[CH3:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[C:6]([CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)[NH:7][C:8]2=[O:13].Br[CH2:21][CH:22]([OH:24])[CH3:23]>>[CH3:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[C:6]([CH:14]1[CH2:19][CH2:18][N:17]([CH2:21][CH:22]([OH:24])[CH3:23])[CH2:16][CH2:15]1)[NH:7][C:8]2=[O:13]

Participants

3

Reactant 2

HCID 297401-Bromo-2-propanolHCID 9965473HCID 9965473, compound

Product 1

HCID 10424886HCID 10424886, compoundYield 13.6%

Procedure

By the reaction in the same manner as in Example 2a, using 5-methyl-3-(piperidin-4-yl)-2H-isoquinolin-1-one hydrochloride (1 g) and 1-bromo-2-propanol (994 mg), 5-methyl-3-[1-(2-hydroxypropyl)piperidin-4-yl]-2H-isoquinolin-1-one (147 mg) was obtained.

Workup

  1. customBy the reaction in the same manner as in Example 2a

Sources & evidence

ORD record
ord-c4c656b14e2140a2a4e616ba7e3d0950
Source dataset
uspto-grants-2010_10
Patent number
US07812178B2

Reaction notes

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