3H-1,3-oxazole-2-thione → 4-(4,5-Dihydro-oxazol-2-ylsulfanyl)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

HRID 1159596Notes

Reaction equation

HRID 1159596 reaction equation
[CH3:1][C:2]1([CH3:15])[O:11][C:10]2[C:5](=[CH:6][C:7]([C:12]#[N:13])=[CH:8][CH:9]=2)[CH:4]2[O:14][CH:3]12.[O:16]1[CH:20]=[CH:19][NH:18][C:17]1=[S:21]>>[O:16]1[CH2:20][CH2:19][N:18]=[C:17]1[S:21][CH:4]1[C:5]2[C:10](=[CH:9][CH:8]=[C:7]([C:12]#[N:13])[CH:6]=2)[O:11][C:2]([CH3:15])([CH3:1])[CH:3]1[OH:14]

Participants

3

Reactant 2

HCID 70592403H-1,3-oxazole-2-thioneHCID 108673602,2-Dimethyl-3,4-epoxy-6-cyanochroman

Product 1

HCID 160406524-(4,5-Dihydro-oxazol-2-ylsulfanyl)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

Procedure

Following the procedure described in the Example 1, using (±) 2,2-dimethyl-1a,7b-dihydro-2H-1,3-dioxa-cyclopropa[a]naphthalene-6-carbonitrile and 3H-oxazole-2-thione as starting materials, the title compound was prepared as a white solid.

Sources & evidence

ORD record
ord-3c56988baedf4a028db7f311483d531e
Source dataset
uspto-grants-2010_10
Patent number
US07812183B2

Reaction notes

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