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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1159596Generated: October 29, 2026

3H-1,3-oxazole-2-thione → 4-(4,5-Dihydro-oxazol-2-ylsulfanyl)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

https://huagongshe.com/reaction/1159596

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3H-1,3-oxazole-2-thioneHCID 7059240—
Reactant2,2-Dimethyl-3,4-epoxy-6-cyanochromanHCID 10867360—
Product4-(4,5-Dihydro-oxazol-2-ylsulfanyl)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrileHCID 16040652—

Reaction Steps

Following the procedure described in the Example 1, using (±) 2,2-dimethyl-1a,7b-dihydro-2H-1,3-dioxa-cyclopropa[a]naphthalene-6-carbonitrile and 3H-oxazole-2-thione as starting materials, the title compound was prepared as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07812183B2
Source datasetuspto-grants-2010_10
ORD IDord-3c56988baedf4a028db7f311483d531e
Source noteuspto-grants-2010_10