反应详情

To 5-(Benzyloxy)-1-(phenylsulfonyl)-1H-indole-4-carbaldehyde, Intermediate 62 205 mg (0.52 mmol) in dichloroethane[DCE] (10 mL) were added BOC-piperazine, 137 mg (0.74 mmol), NaBH(OAc)3, 333 mg (1.6 mmol) and HOAc, 45 mg (0.8 mmol) and the mixture was stirred at room temperature in sealed test tube over night. Water was added, the phases were separated and the dried (MgSO4) organic phase was evaporated at reduced pressure and the black residue was chromatographed on a column of silica with CHCl3 100% as eluent to yield 260 mg (88%) of a blackish oil. MS (ESI+) for C31H35N3O5S m/z 562 (M+H)+.

1. customthe phases were separated
2. dry with materialthe dried (MgSO4) organic phase
3. customwas evaporated at reduced pressure
4. customthe black residue was chromatographed on a column of silica with CHCl3 100% as eluent