Sodium Hydroxide → HCID 68880180, compound

HRID 1159830Notes

Reaction equation

HRID 1159830 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][O:9][C:10]1[C:11]([CH2:28][N:29]([CH3:31])[CH3:30])=[C:12]2[C:16](=[CH:17][CH:18]=1)[N:15](S(C1C=CC=CC=1)(=O)=O)[CH:14]=[CH:13]2.[OH-].[Na+]>CCO>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][O:9][C:10]1[C:11]([CH2:28][N:29]([CH3:30])[CH3:31])=[C:12]2[C:16](=[CH:17][CH:18]=1)[NH:15][CH:14]=[CH:13]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86618262HCID 86618262, compound

Product 1

HCID 68880180HCID 68880180, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

{[5-Methoxy-1-(phenylsulfonyl)-1H-indol-4-yl]methyl}dimethylamine trifluoroacetate (127 mg, 0.278 mmol) was refluxed in EtOH (2 ml) and 1 M NaOH (2 ml) for 3 h. The mixture was extracted with DCM The product was purified on Gilson HPLC using 20-40% MeCN in 0.1% TFA. Yield: 54.6 mg (62%); colourless oil.

Workup

  1. extractionThe mixture was extracted with DCM The product
  2. customwas purified on Gilson HPLC

Sources & evidence

ORD record
ord-e0e3493c0b504cf890660f59100f1fe6
Source dataset
uspto-grants-2010_10
Patent number
US07812017B2

Reaction notes

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