反应详情

To a solution of 1-(5-methoxy-1H-indol-4-yl)-N,N-dimethylmethanamine (15 mg, 0.07 mmol; Intermediate 97) in DMF (1 mL) NaH (4 mg, 0.15 mmol) was added at rt. The reaction mixture was stirred at rt for 15 min and 2,5-dimethoxybenzenesulfonyl chloride (26 mg, 0.11 mmol) was added. The reaction mixture was allowed to stir at rt over night. The reaction was quenched by addition of water. Purification by preparative HPLC/UV (System B) afforded the title product (5 mg, 17%) as a beige solid. MS (ESI+) for C20H24N2O5S m/z 405 (M+H)+.

1. stirringto stir at rt over night
2. customThe reaction was quenched by addition of water
3. customPurification by preparative HPLC/UV (System B)