反应详情

温度

150 °C

To 5-(benzyloxy)-6-methoxy-1-(phenylsulfonyl)-1H-indole (6.6 g, 17 mmol; Intermediate 100) and Pd/C (2 g, 30 wt %), EtOH (30 mL), cyclohexene (9 mL) and HCl (9 mL) were added. The reaction mixture was warmed to 150° C. for 5 min using microwave heating. The Pd/C was filtered off and the solvent was removed under reduced pressure to afford the title compound in quantitative yield (5 g) as a black gum. The product was used without any further purification in the next step. MS (ESI+) for C15H13NO4S m/z 304 (M+H)+.

1. temperatureheating
2. filtrationThe Pd/C was filtered off
3. customthe solvent was removed under reduced pressure