N-{3-[3-(2-Chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide → N-(3-{3-[2-(1,2,3,4-tetrahydro-7-isoquinolinylamino)-4-pyrimidinyl]-pyrazolo[1,5-a]pyridin-2-yl}phenyl)benzamide

HRID 1159915노트

반응식

HRID 1159915 반응식
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:9]([C:17]3[CH:18]=[C:19]([NH:23][C:24](=[O:33])[C:25]4[C:30](F)=[CH:29][CH:28]=[CH:27][C:26]=4F)[CH:20]=[CH:21][CH:22]=3)=[N:10][N:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=23)[CH:5]=[CH:4][N:3]=1.N1C=[CH:37][C:36]([C:39]2[CH:45]=[CH:44][C:42]([NH2:43])=[CH:41][CH:40]=2)=N1.[NH2:46][C:47]1C=CC(C(=O)CC2C=CC=CC=2)=CC=1>>[CH2:47]1[C:40]2[C:39](=[CH:45][CH:44]=[C:42]([NH:43][C:2]3[N:7]=[C:6]([C:8]4[C:9]([C:17]5[CH:18]=[C:19]([NH:23][C:24](=[O:33])[C:25]6[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=6)[CH:20]=[CH:21][CH:22]=5)=[N:10][N:11]5[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=45)[CH:5]=[CH:4][N:3]=3)[CH:41]=2)[CH2:36][CH2:37][NH:46]1

참가 물질

3

반응물 2

HCID 59513803N-{3-[3-(2-Chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamideHCID 178507411HCID 178507411, 화합물

생성물 1

HCID 59513880N-(3-{3-[2-(1,2,3,4-tetrahydro-7-isoquinolinylamino)-4-pyrimidinyl]-pyrazolo[1,5-a]pyridin-2-yl}phenyl)benzamide

실험 절차

The title compound was prepared from N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide and 1-(4-aminophenyl)-2-phenylethanone 4-(1H-pyrazol-3-yl)aniline by a procedure similar to Example 64. 1H NMR (400 MHz, DMSO-d6) δ 4.32 (s, 2H), 6.70 (d, 1H, J=5.2 Hz), 7.17-7.37 (m, 8H), 7.42 (d, 1H, J=7.7 Hz), 7.51-7.65 (m, 3H), 7.86 (d, 1H, J=8.8 Hz), 7.92 (d, 2H, J=9.0 Hz), 8.00 (d, 2H, J=8.8 Hz), 8.06 (s, 1H), 8.40 (d, 1H, J=5.4 Hz), 8.53 (d, 1H, J=9.0 Hz), 8.91 (d, 1H, J=6.8 Hz), 10.09 (s, 1H), 10.98 (s, 1H); ESIMS (M+H)+=636.

출처 및 근거

ORD 기록
ord-c2202c7192ca46178511aba96b8e8a1a
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07812022B2

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