N-{3-[3-(2-Chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide → N-(3-{3-[2-(1,2,3,4-tetrahydro-7-isoquinolinylamino)-4-pyrimidinyl]-pyrazolo[1,5-a]pyridin-2-yl}phenyl)benzamide

Participants

Reaction Steps

The title compound was prepared from N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide and 1-(4-aminophenyl)-2-phenylethanone 4-(1H-pyrazol-3-yl)aniline by a procedure similar to Example 64. 1H NMR (400 MHz, DMSO-d6) δ 4.32 (s, 2H), 6.70 (d, 1H, J=5.2 Hz), 7.17-7.37 (m, 8H), 7.42 (d, 1H, J=7.7 Hz), 7.51-7.65 (m, 3H), 7.86 (d, 1H, J=8.8 Hz), 7.92 (d, 2H, J=9.0 Hz), 8.00 (d, 2H, J=8.8 Hz), 8.06 (s, 1H), 8.40 (d, 1H, J=5.4 Hz), 8.53 (d, 1H, J=9.0 Hz), 8.91 (d, 1H, J=6.8 Hz), 10.09 (s, 1H), 10.98 (s, 1H); ESIMS (M+H)+=636.

Provenance & Evidence