4-(3-(Diethylamino)propoxy)-3-fluoroaniline → N-[3-(3-{2-[{3-[(4-Amino-2-fluorophenyl)oxy]propyl}(methyl)amino]-4-pyrimidinyl}pyrazolo[1,5-a]pyridin-2-yl)phenyl]-2,6-difluorobenzamide

Participants

Role	Name	HCID	Charge
Reactant	4-(3-(Diethylamino)propoxy)-3-fluoroaniline	HCID 21974741	—
Reactant	N-{3-[3-(2-Chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide	HCID 59513803	—
Product	N-[3-(3-{2-[{3-[(4-Amino-2-fluorophenyl)oxy]propyl}(methyl)amino]-4-pyrimidinyl}pyrazolo[1,5-a]pyridin-2-yl)phenyl]-2,6-difluorobenzamide	HCID 59513855	—

Reaction Steps

The title compound was prepared from N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo-[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide and 4-{[3-(diethylamino)-propyl]oxy}-3-fluoroaniline in a manner analogous to Example 27, Step D. HRMS calcd for C37H34F3N7O2: 665.2726; found: 666.2804 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07812022B2
Source dataset	uspto-grants-2010_10
ORD ID	ord-c588bfbb151f4a51a0fd07748a27ec68
Source note	uspto-grants-2010_10