反应详情

To a solution of 2,2,2-trifluoro-N-[2-(methylsulfonyl)ethyl]-N-[(3-nitrophenyl)methyl]acetamide (0.88 g, 2.5 mmol) in 2-propanol (75 mL) was added 10% Pd/C (80 mg). The reaction was stirred at rt under a hydrogen atmosphere (1 atm) for 72 h. The reaction mixture was filtered through Celite, adsorbed to silica, and purified by column chromatography to generate the title compound in 93% yield (0.75 g, 2.3 mmol). 1H NMR (400 MHz, CDCl3): δ 7.17 (t, J=7.9 Hz, 1H), 6.66 (d, J=6.9 Hz, 1H), 6.61 (d, J=7.7 Hz, 1H), 6.53 (s, 1H), 4.62 (s, 2H), 3.72-3.77 (m, 4H), 3.18 (t, J=6.8 Hz, 2H), 3.01 (s, 3H). MS (ESI) m/z=324 [M+H]+.

1. filtrationThe reaction mixture was filtered through Celite
2. custompurified by column chromatography