m-Chloroperbenzoic acid → HCID 59515439, compound

HRID 1160100Notes

Reaction equation

HRID 1160100 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([S:8][CH3:9])[C:5]([C:10]#[N:11])=[C:4]([S:12][CH3:13])[N:3]=1.ClC1C=CC=C(C(OO)=[O:22])C=1>ClCCl>[NH2:1][C:2]1[N:3]=[C:4]([S:12]([CH3:13])=[O:22])[C:5]([C:10]#[N:11])=[C:6]([S:8][CH3:9])[N:7]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 47787545-Pyrimidinecarbonitrile, 2-amino-4,6-bis(methylthio)-

Product 1

HCID 59515439HCID 59515439, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a 50 mL round-bottomed flask were added 2-Amino-4,6-bis-methylsulfanyl-pyrimidine-5-carbonitrile (7:212 mg, 1 mmol, 1.0 eq.), m-chloroperbenzoic acid (2 mmol), and dichloromethane (6 mL). The reaction mixture was stirred at room temperature for 1 hr. The precipitate was filtered and gave to white solid. No further purification was necessary (282 mg). LC-MS: (ES+) m/z 229 (M+1). 1H-NMR, Varian 400 MHz (DMSO-d6) δ 2.85 (s, 3H), 2.47 (s, 3H) ppm.

Workup

  1. filtrationThe precipitate was filtered
  2. customgave to white solid
  3. customNo further purification

Sources & evidence

ORD record
ord-5ea4afe5516e464698f7cc30686f7f19
Source dataset
uspto-grants-2010_10
Patent number
US07816353B2

Reaction notes

Loading…