Hydrazine hydrate (1:1) → HCID 55281993, compound

HRID 1160101Notes

Reaction equation

HRID 1160101 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](S(C)=O)[C:5]([C:11]#[N:12])=[C:4]([S:13][CH3:14])[N:3]=1.O.[NH2:16][NH2:17]>C(#N)C>[NH2:1][C:2]1[N:7]=[C:6]([NH:16][NH2:17])[C:5]([C:11]#[N:12])=[C:4]([S:13][CH3:14])[N:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 59515439HCID 59515439, compound

Product 1

HCID 55281993HCID 55281993, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a 50 mL round-bottomed flask were added 2-Amino-4-methanesulfinyl-6-methylsulfanyl-pyrimidine-5-carbonitrile (8:100 mg, 0.4 mmol.), hydrazine hydrate (0.8 mmol), and acetonitrile (2 mL). The reaction mixture was stirred at room temperature for 4 hr. The precipitate was filtered and gave to white solid. No further purification was necessary (76 mg). LC-MS: (ES+) m/z 197 (M+1).

Workup

  1. filtrationThe precipitate was filtered
  2. customgave to white solid
  3. customNo further purification

Sources & evidence

ORD record
ord-cf04a4baef574dbf8706beee6ffe11a7
Source dataset
uspto-grants-2010_10
Patent number
US07816353B2

Reaction notes

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