Hydrochloric Acid → HCID 58947953, compound

HRID 1160142Notes

Reaction equation

HRID 1160142 reaction equation
[CH3:1][N:2]([CH3:20])[S:3]([CH2:6][C:7]1([NH:13]S(C(C)(C)C)=O)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1)(=[O:5])=[O:4].Cl>CO.O1CCOCC1>[NH2:13][C:7]1([CH2:6][S:3]([N:2]([CH3:20])[CH3:1])(=[O:5])=[O:4])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68631790HCID 68631790, compound

Product 1

HCID 58947953HCID 58947953, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

The sulfinamide 1200-C (1.3 g) was dissolved in 40 mL of methanol and treated with 10 mL of 4M HCl solution in dioxane. The mixture was stirred for about 30 min until all the starting material had been consumed as determined by TLC (20% acetone in dichloromethane/hexanes, 1:1). The mixture was evaporated to dryness. Dichloromethane was added (15 mL) to make a cloudy solution. Upon addition of 100 mL of ether a white precipitated formed. The product 1200-D (1.02 g; 98%) was recovered by filtration using filter paper whatman #1.

Workup

  1. customhad been consumed
  2. customThe mixture was evaporated to dryness
  3. additionDichloromethane was added (15 mL)
  4. additionUpon addition of 100 mL of ether
  5. customa white precipitated
  6. customformed
  7. filtrationThe product 1200-D (1.02 g; 98%) was recovered by filtration
  8. filtrationusing filter paper whatman #1

Sources & evidence

ORD record
ord-d37159225e1b4ffc971a72212b148759
Source dataset
uspto-grants-2010_10
Patent number
US07816326B2

Reaction notes

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