反应详情

To a RT solution of toluene (15 mL) containing acid 1261-F (3.96 mmol, 1.0 g) was added DPPA (0.85 mL, 3.96 mmol) followed by Et3N (0.56 mL, 3.96 mmol). The reaction was stirred at RT for 10 min then refluxed for 2 hours. Reaction was cooled down to RT and diluted with DCM (50 mL). Washed with NaHCO3, brine and organic layer was dried over MgSO4. The volatile were removed and the residue was diluted with DCM (15 mL) to give 1261-G as a 0.26M solution.

1. temperaturethen refluxed for 2 hours
2. customReaction
3. temperaturewas cooled down to RT
4. washWashed with NaHCO3, brine and organic layer
5. dry with materialwas dried over MgSO4
6. customThe volatile were removed
7. additionthe residue was diluted with DCM (15 mL)