Pyridine → HCID 57977997, compound

HRID 1160217Notes

Reaction equation

HRID 1160217 reaction equation
[Cl:1][C:2]1[CH:7]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[C:6](Cl)([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[CH:5]=[N:4][N:3]=1.N1C=CC=CC=1.O.[NH2:30][NH2:31]>O>[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:30][NH2:31])=[C:6]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 24654Hydrazine hydrate (1:1)HCID 68688787HCID 68688787, compound

Product 1

HCID 57977997HCID 57977997, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
120 °C

Procedure

To a r.b. flask was added 3,5-dichloro-4,5-bis(4-chlorophenyl)pyridazine (4.5 gm, 12.2 mmol), pyridine (20 ml) and hydrazine monohydrate (1.494 gm, 30.49 mmol). The reaction mixture was stirred at 120° C. for 1 h. After this time, the reaction mixture was cooled to RT Water (400 ml) was then added and a solid precipitated. The solution was filtered and the solid was collected and air dried overnight to give the title compound, 1-(6-chloro-4,5-bis(4-chlorophenyl)pyridazin-3-yl)hydrazine (3.7 gm, 83% yield) as a solid. MS (M+H)=364.9.

Workup

  1. additionwas then added
  2. customa solid precipitated
  3. filtrationThe solution was filtered
  4. customthe solid was collected
  5. customair dried overnight

Sources & evidence

ORD record
ord-210e16ec8d7a42e888df479794250ebc
Source dataset
uspto-grants-2010_10
Patent number
US07816357B2

Reaction notes

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