反应详情

温度

60 °C

The 1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-(methylamino)butanoate from the previous step (31.4 g) was dissolved in a mixture of MeOH (100 mL) and 4N HCl/dioxane (30 mL) and heated to 60° C. for 1.25 h. The solvents were concentrated to a slurry, Et2O (200 mL) was added, the solid filtered, washed well with Et2O to give the titled compound (15.6 g).

1. concentrationThe solvents were concentrated to a slurry, Et2O (200 mL)
2. additionwas added
3. filtrationthe solid filtered
4. washwashed well with Et2O