HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1160397Generated: October 30, 2026
1,1-Dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-(methylamino)butanoate → Methyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-(methylamino)butanoate, hydrochloride
https://huagongshe.com/reaction/1160397
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,1-Dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-(methylamino)butanoate | HCID 59516257 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Product | Methyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-(methylamino)butanoate, hydrochloride | HCID 131728379 | — |
Reaction Steps
The 1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-(methylamino)butanoate from the previous step (31.4 g) was dissolved in a mixture of MeOH (100 mL) and 4N HCl/dioxane (30 mL) and heated to 60° C. for 1.25 h. The solvents were concentrated to a slurry, Et2O (200 mL) was added, the solid filtered, washed well with Et2O to give the titled compound (15.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07816395B2 |
|---|
| Source dataset | uspto-grants-2010_10 |
|---|
| ORD ID | ord-9cfef89d7617450e80e24c73c4cdc4ed |
|---|
| Source note | uspto-grants-2010_10 |
|---|
