N-methyl-2-pyrrolidone → HCID 11519222, compound

HRID 1160438Notes

Reaction equation

HRID 1160438 reaction equation
C1([CH2:6][CH2:7][NH:8][C:9]([C:11]2[C:12](=[O:30])[C:13]3[CH:27]=[N:26][C:25](SC)=[N:24][C:14]=3[N:15]3[C:23]=2[S:22][C:21]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]3=2)=[O:10])CCCC1.[N:31]1([C:37](=[O:39])[CH3:38])[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1.C[N:41]1[C:45](=O)[CH2:44][CH2:43][CH2:42]1>>[N:41]1([CH2:6][CH2:7][NH:8][C:9]([C:11]2[C:12](=[O:30])[C:13]3[CH:27]=[N:26][C:25]([N:34]4[CH2:35][CH2:36][N:31]([C:37](=[O:39])[CH3:38])[CH2:32][CH2:33]4)=[N:24][C:14]=3[N:15]3[C:23]=2[S:22][C:21]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]3=2)=[O:10])[CH2:45][CH2:44][CH2:43][CH2:42]1

Participants

4

Reactant 3

HCID 13387N-methyl-2-pyrrolidoneHCID 837951-AcetylpiperazineHCID 86604203HCID 86604203, compound

Product 1

HCID 11519222HCID 11519222, compound

Procedure

A solution of 2-methylsulfanyl-5-oxo-5H-7-thia-1,3,11b-triaza-benzo[c]fluorene-6-carboxylic acid (2-cyclopentyl-ethyl)-amide (25 mg, 0.057 mmol) and 1-(piperazin-1-yl)ethanone (75 mg, 0.585 mmol) in NMP (1.0 mL) was heated for 20 min at 200° C. in a microwave. The crude reaction mixture was purified by reverse phase HPLC. MS (m/z): 520 (MH+).

Workup

  1. customThe crude reaction mixture
  2. customwas purified by reverse phase HPLC

Sources & evidence

ORD record
ord-9b50bea554b64a53a4ddea4dc8b6c0be
Source dataset
uspto-grants-2010_10
Patent number
US07816406B2

Reaction notes

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