反应详情

温度

70 °C

A mixture of methyl 3-(hydroxymethyl)-5-[methyl(methylsulfonyl)amino]benzoate obtained in Reference Example 21 1.10 g (4.0 mmol), manganese dioxide 3.38 g (39 mmol) and ethyl acetate (40 mL) was stirred at 70° C. for 2.5 hours. The mixture was filtered on Celite to remove the precipitates, and the solvent was concentrated to give 0.847 g (3.1 mmol) of the title compound (yield: 78%).

1. filtrationThe mixture was filtered on Celite
2. customto remove the precipitates
3. concentrationthe solvent was concentrated