Methanol → HCID 57815135, compound

HRID 1160459Notes

Reaction equation

HRID 1160459 reaction equation
[CH:1]1([CH:4]=[CH:5][C:6]2[CH:7]=[C:8]([CH:12]=[C:13]([N:15]([CH3:20])[S:16]([CH3:19])(=[O:18])=[O:17])[CH:14]=2)[C:9]([OH:11])=[O:10])[CH2:3][CH2:2]1.CO>[Pd].C(OCC)(=O)C>[CH:1]1([CH2:4][CH2:5][C:6]2[CH:7]=[C:8]([CH:12]=[C:13]([N:15]([CH3:20])[S:16]([CH3:19])(=[O:18])=[O:17])[CH:14]=2)[C:9]([OH:11])=[O:10])[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 887MethanolHCID 68645838HCID 68645838, compound

Product 1

HCID 57815135HCID 57815135, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 3-(2-cyclopropylvinyl)-5-[methyl(methylsulfonyl)amino]benzoic acid obtained in Reference Example 23 89 mg (0.30 mmol), 10% Pd/C (50% wet) 30 mg, methanol (1 mL) and ethyl acetate (1 mL) was stirred at room temperature under hydrogen atmosphere for 1.5 hours. The reaction solution was filtered on Celite and the solvent was evaporated to give 89 mg (0.30 mmol, 100%) of the title compound (yield: 100%).

Workup

  1. filtrationThe reaction solution was filtered on Celite
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-763170a983a94f02a2cae6b15edc2148
Source dataset
uspto-grants-2010_10
Patent number
US07816387B2

Reaction notes

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