HCID 68535377, compound → HCID 23028125, compound

HRID 1160756Notes

Reaction equation

HRID 1160756 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([CH:10]=[CH:11][CH3:12])=[N:6][N:5]2[C:13]=1[S:14]([N:17]=CN(CC(C)C)CC(C)C)(=[O:16])=[O:15].ClC1N=C2C=CC(C3CC3)=NN2C=1S(N=CN(CC(C)C)CC(C)C)(=O)=O>>[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[CH3:12])=[N:6][N:5]2[C:13]=1[S:14]([NH2:17])(=[O:15])=[O:16]

Participants

3

Reactant 2

HCID 68535377HCID 68535377, compoundHCID 68535409HCID 68535409, compound

Product 1

HCID 23028125HCID 23028125, compoundYield 70.1%

Procedure

The reaction was carried out in the same manner as in Reference Example 12 except that N′-(2-chloro-6-(1-propenyl)imidazo[1,2-b]pyridazin-3-ylsulfonyl)-N,N-diisobutylformamidine as a mixture of E and Z was used in place of N′-(2-chloro-6-cyclopropylimidazo[1,2-b]pyridazin-3-ylsulfonyl)-N,N-diisobutylformamidine. The resulting crystals were purified by silica gel column chromatography (chloroform:methanol=20:1), to give the title compound as white crystals. The yield was 70.1%.

Workup

  1. customThe resulting crystals were purified by silica gel column chromatography (chloroform:methanol=20:1)

Sources & evidence

ORD record
ord-32102524526f415f9505cd23f91323ac
Source dataset
uspto-grants-2010_10
Patent number
US07816526B2

Reaction notes

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