HCID 68535377, compound → HCID 23028125, compound

Participants

Reaction Steps

The reaction was carried out in the same manner as in Reference Example 12 except that N′-(2-chloro-6-(1-propenyl)imidazo[1,2-b]pyridazin-3-ylsulfonyl)-N,N-diisobutylformamidine as a mixture of E and Z was used in place of N′-(2-chloro-6-cyclopropylimidazo[1,2-b]pyridazin-3-ylsulfonyl)-N,N-diisobutylformamidine. The resulting crystals were purified by silica gel column chromatography (chloroform:methanol=20:1), to give the title compound as white crystals. The yield was 70.1%.

Provenance & Evidence