Hydrochloric Acid → 2-Ethylsulfonyl-6-n-propylimidazo[1,2-b]pyridazin-3-ylsulfonamide

HRID 1160761Notes

Reaction equation

[CH2:1]([S:3][C:4]1[N:5]=[C:6]2[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][CH3:14])=[N:8][N:7]2[C:15]=1[S:16]([NH2:19])(=[O:18])=[O:17])[CH3:2].C([O-])([O-])=[O:21].C([O-])([O-])=O.OO.OO.OO.[Na+].[Na+].[Na+].[Na+].Cl.[OH2:39]>C(#N)C>[CH2:1]([S:3]([C:4]1[N:5]=[C:6]2[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][CH3:14])=[N:8][N:7]2[C:15]=1[S:16]([NH2:19])(=[O:17])=[O:18])(=[O:21])=[O:39])[CH3:2]

Participants

Conditions

Temperature: 55 °C

Procedure

2-Ethylthio-6-n-propylimidazo[1,2-b]pyridazin-3-ylsulfonamide (0.30 g, 1.00 mmol) was suspended in acetonitrile (1.0 ml) and water (4.0 ml), and sodium percarbonate (effective oxygen concentration, 12.2%; 0.33 g; 2.50 mmol) was added thereto at 45° C. and stirred at 50 to 60° C. for 2.5 hours. The reaction mixture was poured into water and acidified with dilute hydrochloric acid, and the precipitated insoluble solids were collected by filtration and washed with water, to give the title compound as white crystals. The yield was 0.25 g (75.3%).

Workup

filtrationthe precipitated insoluble solids were collected by filtration
washwashed with water

Sources & evidence

ORD record: ord-a9aac78e05304edbab31ed6d61e29c55
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07816526B2

Reaction notes

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