Hydrochloric Acid → HCID 23028116, compound

HRID 1160770Notes

Reaction equation

HRID 1160770 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([S:14]([NH2:17])(=[O:16])=[O:15])=[C:9]([CH2:11][CH2:12][CH3:13])[N:10]=2)[N:7]=1.[CH3:18][NH:19][CH3:20].C(O)(C)(C)C.Cl>O>[CH3:18][N:19]([CH3:20])[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([S:14]([NH2:17])(=[O:16])=[O:15])=[C:9]([CH2:11][CH2:12][CH3:13])[N:10]=2)[N:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 674DimethylamineHCID 6386tert-ButanolHCID 23028149HCID 23028149, compound

Product 1

HCID 23028116HCID 23028116, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 6-chloro-2-n-propylimidazo[1,2-b]pyridazin-3-ylsulfonamide (0.50 g, 1.81 mmol), 50% aqueous dimethylamine (1.0 ml) and t-butanol (5.0 ml) was heated at 100° C. for 8 hours with stirring in a sealed tube reactor. The reaction solution was left and cooled to room temperature, poured into water (50.0 ml) and adjusted to pH 6 with dilute hydrochloric acid, to precipitate crystals which were then filtered and washed with water, to give the title compound as pale yellow crystals. The yield was 0.38 g (74.0%).

Workup

  1. waitThe reaction solution was left
  2. temperaturecooled to room temperature
  3. customto precipitate crystals which
  4. filtrationwere then filtered
  5. washwashed with water

Sources & evidence

ORD record
ord-8452368dc1a044f9873d2aa91bf97a00
Source dataset
uspto-grants-2010_10
Patent number
US07816526B2

Reaction notes

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