反应详情

To a solution of N-methoxy-N-methyl-terephthalamic acid methyl ester (4.56 g, 20.4 mmol) in THF (100 mL) is added PrMgCl (2.0M, 30.6 mmol) at 0° C., the reaction is warmed to room temperature, stirred overnight, quenched by NH4Cl aqueous solution, extracted with ethyl acetate. The combined organic layers are washed with brine, dried over sodium sulfate, concentrate. Column chromatography on silica gel gives the title compound (1 g, 23.7%).

1. customquenched by NH4Cl aqueous solution
2. extractionextracted with ethyl acetate
3. washThe combined organic layers are washed with brine
4. dry with materialdried over sodium sulfate
5. concentrationconcentrate