反应详情

To a solution of 4-butyryl-benzoic acid methyl ester (400 mg, 1.94 mmol) in ethanol (5 mL) and THF (4 mL) is added sodium borohydride (110 mg, 2.9 mmol), the mixture is stirred at room temperature for 2 h. The reaction mixture is quenched by acetic acid (0.5 mL) and water (10 mL), extracted with ethyl acetate. Combined organic layers are washed with brine and dried over sodium sulfate. Concentration and column chromatography on silica gel gives the title compound (370 mg).

1. customThe reaction mixture is quenched by acetic acid (0.5 mL) and water (10 mL)
2. extractionextracted with ethyl acetate
3. washCombined organic layers are washed with brine
4. dry with materialdried over sodium sulfate
5. concentrationConcentration and column chromatography on silica gel