反应详情

To the solution of 3-{4-[1-(2-formyl-4′-isopropyl-biphenyl-4-yloxy)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester (36 mg, 0.07 mmol) in methanol (5 ml) is added NaBH4 (3 mg, 0.07 mmol). After 2 h, the mixture is diluted with ethyl acetate, washed with 1N HCl, water, brine, dried over MgSO4, and concentrated. The residue is taken into methanol (20 mL), followed by the addition of sodium hydroxide (5 N aqueous, 1 mL), stirred for 4 h. The reaction mixture is concentrated and acidified by 5 N HCl (1 mL), extracted with ethyl acetate. Combined organic layers are washed with water and brine, dried over sodium sulfate. Concentration gives the title compound (93 mg) as a white solid. MS (ES): 502.2 [M−H]−.

1. washwashed with 1N HCl, water, brine
2. dry with materialdried over MgSO4
3. concentrationconcentrated
4. additionfollowed by the addition of sodium hydroxide (5 N aqueous, 1 mL)
5. concentrationThe reaction mixture is concentrated
6. extractionextracted with ethyl acetate
7. washCombined organic layers are washed with water and brine
8. dry with materialdried over sodium sulfate
9. concentrationConcentration