HRID1160964

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID140846

1-Bromo-2,4,6-triisopropylbenzene

C15H23Br

结构：COC(=O)CCNC(=O)c1ccc(C(CCCC(F)(F)F)Oc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)cc1

HCID67153418

未命名化合物

PRODUCTS

生成物

结构：CC(C)c1cc(C(C)C)c(OC(CCCC(F)(F)F)c2ccc(C(=O)NCCC(=O)O)cc2)c(C(C)C)c1

HCID67153640

未命名化合物

PROCEDURE

实验过程

The title compound is prepared in a manner substantially similar to Example 359 starting from 3-(4-{5,5,5-trifluoro-1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-pentyl}-benzoylamino)-propionic acid methyl ester and 2-bromo-1,3,5-triisopropyl-benzene. MS: 610.2 [M−H]−.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-715d64723eb4453caef50f3c516dc09e
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07816557B2
来源说明: uspto-grants-2010_10

反应 SMILES

C[O:2][C:3](=[O:39])[CH2:4][CH2:5][NH:6][C:7](=[O:38])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([O:22]C2C=CC(B3OC(C)(C)C(C)(C)O3)=CC=2)[CH2:15][CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[CH:10][CH:9]=1.Br[C:41]1[C:46]([CH:47]([CH3:49])[CH3:48])=[CH:45][C:44]([CH:50]([CH3:52])[CH3:51])=[CH:43][C:42]=1[CH:53]([CH3:55])[CH3:54]>>[CH:53]([C:42]1[CH:43]=[C:44]([CH:50]([CH3:52])[CH3:51])[CH:45]=[C:46]([CH:47]([CH3:49])[CH3:48])[C:41]=1[O:22][CH:14]([C:11]1[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:39])=[O:2])=[O:38])=[CH:9][CH:10]=1)[CH2:15][CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19])([CH3:55])[CH3:54]