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HRID 1160964作成日：2026年10月25日

1-Bromo-2,4,6-triisopropylbenzene → Racemic 3-{4-[1-(2,4,6-triisopropyl-phenoxy)-5,5,5-trifluoro-pentyl]-benzoylamino}-propionic acid

https://huagongshe.com/reaction/1160964

反応式

関与物質

役割名称HCID仕込み量
反応物1-Bromo-2,4,6-triisopropylbenzeneHCID 140846—
反応物3-(4-{5,5,5-Trifluoro-1-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenoxy]-pentyl}-benzoylamino)-propionic acid methyl esterHCID 67153418—
生成物Racemic 3-{4-[1-(2,4,6-triisopropyl-phenoxy)-5,5,5-trifluoro-pentyl]-benzoylamino}-propionic acidHCID 67153640—

反応手順

The title compound is prepared in a manner substantially similar to Example 359 starting from 3-(4-{5,5,5-trifluoro-1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-pentyl}-benzoylamino)-propionic acid methyl ester and 2-bromo-1,3,5-triisopropyl-benzene. MS: 610.2 [M−H]−.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07816557B2
出典データセットuspto-grants-2010_10
ORD IDord-715d64723eb4453caef50f3c516dc09e
出典メモuspto-grants-2010_10