1,1,1-Trifluoro-2-(4-iodo-phenyl)-propan-2-ol → 8-(Isobutylsulfonyl)-2-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)-2,8-diazaspiro[4.5]decan-1-one
Reaction equation
[CH2:19]([S:20]([N:21]1[CH2:22][CH2:23][C:24]2([C:25](=[O:26])[N:27]([c:28]3[cH:29][cH:30][c:31]([CH:32]([OH:33])[C:34]([F:35])([F:36])[F:37])[cH:38][cH:39]3)[CH2:40][CH2:41]2)[CH2:42][CH2:43]1)(=[O:44])=[O:45])[CH:46]([CH3:47])[CH3:48].[CH2:1]([CH:2]([CH3:3])[CH3:4])[S:5](=[O:6])(=[O:7])[N:8]1[CH2:9][CH2:10][C:11]2([CH2:12][CH2:13][NH:14][C:15]2=[O:16])[CH2:17][CH2:18]1.[F:49][C:50]([C:51]([CH3:52])([OH:53])[c:54]1[cH:55][cH:56][c:57]([I:60])[cH:58][cH:59]1)([F:61])[F:62]>>[CH2:1]([CH:2]([CH3:3])[CH3:4])[S:5](=[O:6])(=[O:7])[N:8]1[CH2:9][CH2:10][C:11]2([CH2:12][CH2:13][N:14]([c:57]3[cH:56][cH:55][c:54]([C:51]([C:50]([F:49])([F:61])[F:62])([CH3:52])[OH:53])[cH:59][cH:58]3)[C:15]2=[O:16])[CH2:17][CH2:18]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-18fd4b80f758410da708629a5299ee4f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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