HCID 66699501, compound → HCID 57438328, compound

HRID 1161052Notes

Reaction equation

HRID 1161052 reaction equation
[NH:1]1[CH:5]=[N:4][N:3]=[N:2]1.[C:6]([C:9]1[CH:40]=[CH:39][C:12]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([CH:21]([O:32][CH:33]3[CH2:38][CH2:37][CH2:36][CH2:35][O:34]3)[C:22]3[CH:23]=[CH:24][C:25]([O:30][CH3:31])=[C:26]([CH:29]=3)C#N)=[CH:17][CH:16]=2)=[C:11]([CH2:41][CH2:42][CH3:43])[C:10]=1[OH:44])(=[O:8])[CH3:7]>>[OH:44][C:10]1[C:11]([CH2:41][CH2:42][CH3:43])=[C:12]([O:13][CH2:14][C:15]2[CH:16]=[CH:17][C:18]([CH:21]([C:22]3[CH:29]=[CH:26][C:25]([O:30][CH3:31])=[C:24]([C:5]4[N:1]=[N:2][NH:3][N:4]=4)[CH:23]=3)[O:32][CH:33]3[CH2:38][CH2:37][CH2:36][CH2:35][O:34]3)=[CH:19][CH:20]=2)[CH:39]=[CH:40][C:9]=1[C:6](=[O:8])[CH3:7]

Participants

3

Reactant 2

HCID 66699501HCID 66699501, compoundHCID 178418441HCID 178418441, compound

Product 1

HCID 57438328HCID 57438328, compound

Procedure

Using the method of tetrazole formation described in Example 1 with 5-[[4-(4-acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenyl]-(tetrahydro-pyran-2-yloxy)-methyl]-2-methoxy-benzonitrile (1.00 g, 1.89 mmol), the title compound is obtained (0.620 g, 1.10 mmol, 58%): MS (m/z): 571 (M−1).

Sources & evidence

ORD record
ord-083cd0eb2ef74759a785899a4b339448
Source dataset
uspto-grants-2010_10
Patent number
US07816523B2

Reaction notes

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