Hydroxyamine hydrochloride → HCID 178492604, compound

HRID 1161154Notes

Reaction equation

HRID 1161154 reaction equation
C([O-])(=O)C.[Na+].[CH3:6][O:7][C:8]1[CH:17]=[CH:16][C:11]([O:12][CH2:13][C:14]#[N:15])=[CH:10][CH:9]=1.Cl.[NH2:19][OH:20]>CO>[OH:20][NH:19][C:14](=[NH:15])[CH2:13][O:12][C:11]1[CH:16]=[CH:17][C:8]([O:7][CH3:6])=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 5794914-Methoxyphenoxyacetonitrile

Product 1

HCID 178492604HCID 178492604, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Add sodium acetate (5.1 g, 62 mmol) to 4-methoxyphenoxyacetonitrile (5.0 g, 31 mmol) and hydroxylamine hydrochloride (4.3 g, 62 mmol) in methanol (100 mL). Stir the resulting mixture at room temperature for 20 hours. Filter the resulting mixture through Celite, concentrate, stir in chloroform for 18 hours and filter. Concentrate the resulting solution to the title compound (5.1 g). LC-MS (m/e): 197 (M+1).

Workup

  1. filtrationFilter the resulting mixture through Celite
  2. concentrationconcentrate
  3. stirringstir in chloroform for 18 hours
  4. filtrationfilter
  5. concentrationConcentrate the resulting solution to the title compound (5.1 g)

Sources & evidence

ORD record
ord-30ec63512a284e66a58bf28b0d680ab0
Source dataset
uspto-grants-2010_10
Patent number
US07816523B2

Reaction notes

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