HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 5-Amino-2-(1,3-dihydroxypropan-2-yl)isoquinolin-1(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-(1,3-Dihydroxypropan-2-yl)-5-nitroisoquinolin-1(2H)-one | HCID 59515763 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 5-Amino-2-(1,3-dihydroxypropan-2-yl)isoquinolin-1(2H)-one | HCID 59515794 | — |
Reaction Steps
2-(1,3-dihydroxypropan-2-yl)-5-nitroisoquinolin-1(2H)-one (1.2 g, 0.0045 mol) was stirred with palladium 10% wt. on calcium carbonate (0.1 g, 0.0005 mol) in methanol (100 mL, 2 mol) under hydrogen (balloon) over 1 hr at room temperature. The catalyst was filtered, the filtrate was concentrated to dryness gave light green oil. MS m/z=235.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07816371B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-b19a09a297184d689cbac23d448ed8af |
| Source note | uspto-grants-2010_10 |