反应详情

A round bottom flask was charged with (R)-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide (5.0 g, 0.018 mol), palladium on charcoal (10%) (0.3 g, 0.003 mol) and methanol (200 mL, 5 mol) and ethylacetate (80 mL). The reaction mixture was stirred under hydrogen (1 atm) at room temperature for 40 minutes. The mixture was filtered over celite, the solvent was removed to yield the product as a light yellow solid. MS m/z=232.3 (M+H).

1. filtrationThe mixture was filtered over celite
2. customthe solvent was removed