反应详情

Into a round bottom flask was combined (R)-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide (5.0 g, 0.018 mol), palladium on C (0.3 g, 0.003 mol) and methanol (200 mL, 5 mol) (about 80 mL EtOAc was added to dissolve the reactants). The reaction mixture was stirred under hydrogen balloon at room temperature for 40 min. The mixture was filtered over celite, MeOH was removed and a solid was obtained (4.02 g). MS m/z=232.4 (M+1).

1. customInto a round bottom flask was combined
2. dissolutionto dissolve the reactants)
3. filtrationThe mixture was filtered over celite, MeOH
4. customwas removed
5. customa solid was obtained (4.02 g)