HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1161237Generated: October 28, 2026
Methanol → (R)-2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)-2-phenylacetamide
https://huagongshe.com/reaction/1161237
Participants
| Role | Name | HCID | Charge |
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| Reactant | Methanol | HCID 887 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-nitro-1H-isochromen-1-one | HCID 10012760 | — |
| Reactant | (R)-2-Amino-2-phenylacetamide hydrochloride | HCID 16216957 | — |
| Product | (R)-2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)-2-phenylacetamide | HCID 59515684 | — |
Reaction Steps
A round bottom flask was charged with 5-nitro-isochromen-1-one (2 g, 0.01 mol), methanol (20 mL, 0.5 mol), triethylamine (3 mL, 0.02 mol) and (R)-2-amino-2-phenylacetamide hydrochloride (2.3 g, 0.012 mol) and the reaction heated at 50° C. for 3 hours. The starting material disappeared and the solvent was removed under reduced pressure and the residue purified by flash chromatography (40 g silica gel, 0-10% MeOH/DCM) to obtain the product as a brown solid. MS m/z=324.3 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07816371B2 |
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| Source dataset | uspto-grants-2010_10 |
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| ORD ID | ord-ff7ce1f2cd414c7dbe81675e1a5035d4 |
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| Source note | uspto-grants-2010_10 |
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