反应详情

温度

50 °C

A round bottom flask was charged with 5-nitro-isochromen-1-one (2 g, 0.01 mol), methanol (20 mL, 0.5 mol), triethylamine (3 mL, 0.02 mol) and (R)-2-amino-2-phenylacetamide hydrochloride (2.3 g, 0.012 mol) and the reaction heated at 50° C. for 3 hours. The starting material disappeared and the solvent was removed under reduced pressure and the residue purified by flash chromatography (40 g silica gel, 0-10% MeOH/DCM) to obtain the product as a brown solid. MS m/z=324.3 (M+H).

1. customthe solvent was removed under reduced pressure
2. customthe residue purified by flash chromatography (40 g silica gel, 0-10% MeOH/DCM)