HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → (R)-Methyl 2-(5-amino-1-oxoisoquinolin-2(1H)-yl)-3-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | (R)-Methyl 3-methyl-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)butanoate | HCID 59515729 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | (R)-Methyl 2-(5-amino-1-oxoisoquinolin-2(1H)-yl)-3-methylbutanoate | HCID 59515897 | — |
Reaction Steps
(R)-methyl 3-methyl-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)butanoate (2.8 g, 0.0091 mol) was stirred with palladium 10% wt. on calcium carbonate (0.23 g, 0.00011 mol) in methanol (40 mL, 1 mol) under hydrogen (balloon) over 1 h at room temperature. The catalyst was filtered, the filtrate was concentrated to dryness and yielded a yellow oil. MS m/z 274.8 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07816371B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-2a0bbf4aa973420faf127f1497f0c772 |
| Source note | uspto-grants-2010_10 |