Methanol → HCID 59515704, compound

HRID 1161266Notes

Reaction equation

HRID 1161266 reaction equation
[CH3:1][O:2][C:3]1[C:4]([N+:19]([O-])=O)=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[N:8]([C@H:14]([CH3:18])[C:15]([NH2:17])=[O:16])[CH:7]=[CH:6]2.CO>[Pd]>[NH2:19][C:4]1[C:3]([O:2][CH3:1])=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@H:14]([CH3:18])[C:15]([NH2:17])=[O:16])[C:9]2=[O:13]

Participants

4

Reactant 2

HCID 887MethanolHCID 59515798HCID 59515798, compound

Product 1

HCID 59515704HCID 59515704, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of (R)-2-(6-methoxy-5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide (200 mg, 0.0007 mol), methanol (20 mL, 0.5 mol) and palladium, 10% weight on charcoal (21 mg, 0.00017 mol) was stirred under hydrogen (1 atm) for 3 h. The reaction mixture was filtered over celite and the solvent removed to obtain the product as a brown solid. MS m/z=263.3 (M+H).

Workup

  1. filtrationThe reaction mixture was filtered over celite
  2. customthe solvent removed

Sources & evidence

ORD record
ord-5bd5d159e6ac42d69247a7abeedfc090
Source dataset
uspto-grants-2010_10
Patent number
US07816371B2

Reaction notes

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