HRID1161278
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
CONDITIONS
反应条件
- 温度
- 40 °C
PROCEDURE
实验过程
A vial was charged with (R)-2-(5-amino-6-chloro-1-oxoisoquinolin-2(1H)-yl)propyl acetate (160 mg, 0.00054 mol), methylene chloride (10 mL, 0.2 mol), 2-(3-fluoro-4-(trifluoromethyl)phenyl)acetic acid (145 mg, 0.000651 mol), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (413 mg, 0.00108 mol), and N,N-diisopropylethylamine (0.189 mL, 0.00108 mol), and was stirred at 40° C. for 2 days. The reaction was only 50% complete. The solvent was removed and the residue purified by flash chromatography (0-75% ethylacetate/hexane) to obtain the product as a colorless oil. MS m/z=499.3 (M+H)
WORKUP
后处理
- customThe solvent was removed
- customthe residue purified by flash chromatography (0-75% ethylacetate/hexane)