HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → [2-(4-Chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-(4-Chlorophenyl)benzimidazole | HCID 759417 | — |
| Reactant | Ethyl 2-bromo-2-cyclohexylacetate | HCID 2762757 | — |
| Reactant | 3-Chloro-4-{2-[2-(6-chloro-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-benzoic acid | HCID 44197691 | — |
| Product | [2-(4-Chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid ethyl ester | HCID 66619211 | 58% |
Reaction Steps
This compound was synthesized in analogy to example 22, intermediate b, from 2-(4-chloro-phenyl)-1H-benzoimidazole (commercially available), bromo-cyclohexyl-acetic acid ethyl ester (commercially available) and cesium carbonate, to provide the final compound as a colorless solid (58%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07816540B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-5849d97e7a2045bab7823dcca6ea8bc2 |
| Source note | uspto-grants-2010_10 |