4-Amino-3-chlorobenzoic acid → 3-Chloro-4-{2-[2-(4-chloro-phenyl)-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-benzoic acid methyl ester

HRID 1161328Notes

Reaction equation

HRID 1161328 reaction equation
[CH2:1]([O:3][C:4](=[O:39])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:38])[CH:13]([N:20]2[C:24]3[CH:25]=[C:26](F)[C:27](F)=[CH:28][C:23]=3[N:22]=[C:21]2[C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)[CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:7][CH:6]=1)C.[Cl:40]C1C=CC(C2N(C(C3CCCCC3)C(O)=O)C3C=CC=CC=3N=2)=CC=1.NC1C=CC(C(O)=O)=CC=1Cl>N1C=CC=CC=1>[CH3:1][O:3][C:4](=[O:39])[C:5]1[CH:6]=[CH:7][C:8]([NH:11][C:12](=[O:38])[CH:13]([N:20]2[C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[N:22]=[C:21]2[C:31]2[CH:32]=[CH:33][C:34]([Cl:37])=[CH:35][CH:36]=2)[CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:9]([Cl:40])[CH:10]=1

Participants

5

Reactant 3

HCID 172114-Amino-3-chlorobenzoic acidHCID 686454934-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-benzoic acid ethyl esterHCID 68645792HCID 68645792, compound

Product 1

HCID 686452253-Chloro-4-{2-[2-(4-chloro-phenyl)-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-benzoic acid methyl ester

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound was synthesized in analogy to example 22, intermediate d, from [2-(4-chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid, 4-amino-3-chloro-benzoic acid and using pyridine as a base.

Sources & evidence

ORD record
ord-fa915b4f945948319dbb767e32f374a5
Source dataset
uspto-grants-2010_10
Patent number
US07816540B2

Reaction notes

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