HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-3-chlorobenzoic acid → 3-Chloro-4-{2-[2-(4-chloro-phenyl)-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-3-chlorobenzoic acid | HCID 17211 | — |
| Reactant | 4-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-benzoic acid ethyl ester | HCID 68645493 | — |
| Reactant | HCID 68645792 | HCID 68645792 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-Chloro-4-{2-[2-(4-chloro-phenyl)-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-benzoic acid methyl ester | HCID 68645225 | — |
Reaction Steps
The title compound was synthesized in analogy to example 22, intermediate d, from [2-(4-chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid, 4-amino-3-chloro-benzoic acid and using pyridine as a base.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07816540B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-fa915b4f945948319dbb767e32f374a5 |
| Source note | uspto-grants-2010_10 |