HRID1161337

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66905628

未命名化合物

结构：CCOC(=O)c1ccc(NC(=O)C(C2CCCCC2)n2c(-c3ccc(Cl)cc3)nc3cc(F)c(F)cc32)cc1

HCID68645493

未命名化合物

结构：O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)C(C1CCCCC1)n1c(-c2ccc(Cl)cc2)nc2cc(F)ccc21

HCID178523387

未命名化合物

2 次

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)CCc1ccc(NC(=O)C(C2CCCCC2)n2c(-c3ccc(Cl)cc3)nc3cc(F)c(F)cc32)c(F)c1

HCID68645286

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

PROCEDURE

实验过程

The title compound was synthesized in analogy to example 22, intermediate d, from [2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid (example 20, intermediate c), 3-(4-amino-3-fluoro-phenyl)-propionic acid tert-butyl ester and using 4-(dimethylamino)pyridine as base. Light brown foam (78%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9796e53206a2472d8e2562a75edbb8bf
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07816540B2
来源说明: uspto-grants-2010_10

反应 SMILES

C(OC(=O)C1C=CC(N[C:12](=[O:38])[CH:13]([N:20]2[C:24]3[CH:25]=[C:26]([F:30])[C:27]([F:29])=[CH:28][C:23]=3[N:22]=[C:21]2[C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)[CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=CC=1)C.ClC1C=CC(C2N(C(C3CCCCC3)C(NC[C@H]3CC[C@H](C(O)=O)CC3)=O)C3C=CC(F)=CC=3N=2)=CC=1.[C:77]([O:81][C:82](=[O:93])[CH2:83][CH2:84][C:85]1[CH:90]=[CH:89][C:88]([NH2:91])=[C:87]([F:92])[CH:86]=1)([CH3:80])([CH3:79])[CH3:78]>CN(C)C1C=CN=CC=1>[C:77]([O:81][C:82](=[O:93])[CH2:83][CH2:84][C:85]1[CH:90]=[CH:89][C:88]([NH:91][C:12](=[O:38])[CH:13]([N:20]2[C:24]3[CH:25]=[C:26]([F:30])[C:27]([F:29])=[CH:28][C:23]=3[N:22]=[C:21]2[C:31]2[CH:32]=[CH:33][C:34]([Cl:37])=[CH:35][CH:36]=2)[CH:14]2[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]2)=[C:87]([F:92])[CH:86]=1)([CH3:80])([CH3:78])[CH3:79]