Methyl 6-aminonicotinate → 6-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-nicotinic acid methyl ester

HRID 1161345Notes

Reaction equation

HRID 1161345 reaction equation
ClC1C=CC(C2N(C(C3CCCCC3)C(NC[C@H]3CC[C@H](C(O)=O)CC3)=O)C3C=CC(F)=CC=3N=2)=CC=1.[Cl:38][C:39]1[CH:44]=[CH:43][C:42]([C:45]2[N:49]([CH:50]([CH:54]3[CH2:59][CH2:58][CH2:57][CH2:56][CH2:55]3)[C:51](O)=[O:52])[C:48]3[CH:60]=[C:61]([F:65])[C:62]([F:64])=[CH:63][C:47]=3[N:46]=2)=[CH:41][CH:40]=1.[NH2:66][C:67]1[CH:76]=[CH:75][C:70]([C:71]([O:73][CH3:74])=[O:72])=[CH:69][N:68]=1>>[CH3:74][O:73][C:71](=[O:72])[C:70]1[CH:75]=[CH:76][C:67]([NH:66][C:51](=[O:52])[CH:50]([N:49]2[C:48]3[CH:60]=[C:61]([F:65])[C:62]([F:64])=[CH:63][C:47]=3[N:46]=[C:45]2[C:42]2[CH:41]=[CH:40][C:39]([Cl:38])=[CH:44][CH:43]=2)[CH:54]2[CH2:55][CH2:56][CH2:57][CH2:58][CH2:59]2)=[N:68][CH:69]=1

Participants

4

Reactant 3

HCID 737487Methyl 6-aminonicotinateHCID 66619321[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acidHCID 178523387HCID 178523387, compound

Product 1

HCID 686452646-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-nicotinic acid methyl ester

Procedure

The title compound was prepared according to Example 22, intermediate c), from [2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid and methyl 6-aminonicotinate.

Sources & evidence

ORD record
ord-846f773625174814bb2bec55f3902dc0
Source dataset
uspto-grants-2010_10
Patent number
US07816540B2

Reaction notes

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