HCID 59516907, compound → HCID 59517045, compound

HRID 1161370Notes

Reaction equation

HRID 1161370 reaction equation
[CH3:1][S:2][C:3](=[NH:25])[CH:4]([NH:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=1)[C:5]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]([O:13][CH3:14])[C:6]=1[F:15]>C(OCC)(=O)C.[O-2].[O-2].[Mn+4]>[CH3:1][S:2][C:3](=[NH:25])[C:4](=[N:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]#[N:24])=[CH:21][CH:22]=1)[C:5]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]([O:13][CH3:14])[C:6]=1[F:15]

Participants

4

Reactant 1

HCID 59516907HCID 59516907, compound

Product 1

HCID 59517045HCID 59517045, compoundYield 98.6%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

After adding 4.95 g of manganese dioxide to a solution of 2.05 g of 2-(4-cyanophenylamino)-2-(2-fluoro-3,5-dimethoxyphenyl)thioacetimidic acid methyl ester in 100 ml of ethyl acetate, the mixture was stirred at room temperature for 3 hours. The reaction mixture was filtered through celite, and the celite was washed with 500 ml of ethyl acetate. The organic layers were combined and concentrated under reduced pressure. The title compound (2.01 g) was obtained as a light yellow solid.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. washthe celite was washed with 500 ml of ethyl acetate
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-8b2aa21dc3c242e4b99b807f4eb3fba6
Source dataset
uspto-grants-2010_10
Patent number
US07816522B2

Reaction notes

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